|Recently, I received a large number of angry comments about my preferences Nolvadex over Clomid, which I use in all cases (at least in the field of bodybuilding); as an antiestrogen, like a drug to maintain good cholesterol and a testosterone stimulant. In any event, most people use Nolvadex instead of Clomid for controlling ginekomestiey. As for cholesterol, most people do not pay attention to this important issue. But when it comes to using Nolvadex for raising the endogenous production of testosterone, most bodybuilders do not want to hear about it. They apparently only want Clomid. I can only guess that this is based on a profound misunderstanding of the effect of these drugs. Thus, in this article I would like to discuss the features of these two agents, and explain clearly the benefits of Nolvadex in particular to increase the production of testosterone.
Kłomino and Nolvadex
I do not know why Clomid and Nolvadex became so different in the minds of bodybuilders. Definitely they are not solely responsible to be. Clomid and Nolvadex are anti-estrogens belonging to the same group trifeniletilenov. They are structurally similar and are classified as selective estrogen receptor modulators with mixed agonistic and antagonistic properties. This means that in certain tissue, they block the action of estrogen receptors by binding, while in other tissues could act as a real estrogen receptors activating. In men, both drugs act as anti-estrogens in their ability to interfere with estrogen negative feedback on the hypothalamus and stimulate the increased production of GnRH (GnRH). This will result in increased production of luteinizing hormone by the pituitary gland, which in turn can increase the production of testosterone by the testes. This makes both drugs, but for some reason bodybuilders continue to think that only good for Clomid testosterone stimulation. In this article you will find some research that Nolvadex can not only be used for the same purposes, but in fact should be the preferred drug of the two.
Studies conducted in the late ’70s in the University of Ghent in Belgium make clear the advantages of Nolvadex over Clomid to increase the level of testosterone (1). Researchers looked at the effect of Nolvadex and Clomid on the endocrine system of healthy men, as well as those Thyroid and Migraine who have suffered from low sperm counts (oligospermia). For our purposes it is obviously most interested in the effects of these drugs on healthy men. At the beginning of the study is quite instructive results were found.Nolvadex when used within 10 days at a dosage of 20 mg per day increased the level of testosterone in the serum of 142% of the initial level that was comparable with the effect of 150 mg of Clomid per day for the same period of time (increase testosterone levels were slightly, but not significantly more Clomid). We must remember that this is the effect of three 50mg tablet of Clomid. At about the same price 50mg Clomid and 20mg Nolvadex we can already see a difference in relation to the price / benefit result in Nolvadex.
The sensitivity of the pituitary to GnRH.
But there is something more interesting. The researchers also conducted tests on GnRH stimulation before and after administration of Nolvadex and Clomid and these two drugs showed significantly different results. These tests included the introduction patsientav 100mcg of GnRH and measuring the production of pituitary LH in response. The purpose of this test was to see how sensitive the pituitary to GnRH. The more sensitive the pituitary, the more is produced luteinizing hormone. Tests have shown that after ten days of treatment with Nolvadex pituitary sensitivity to GnRH increased slightly compared with the state before the reception. This contrasts with the 10-day intake 150mg Clomid, which showed a decrease in the sensitivity of the pituitary to GnRH (luteinizing hormone is produced longer before receiving). As the study with Nolvadex continued until 6 weeks, pituitary sensitivity to GnRH increased significantly compared with the state before the reception or the 10-day level. In this case, the same 20 mg caused an increase in testosterone and luteinizing hormone by an average of 183% and 172% of the initial values, respectively, which is significantly higher than it was during the 10-day treatment. For 10-day application of Clomid causes a slight decrease in sensitivity of the pituitary to GnRH, while prolonged use of Nolvadex is only increasing pituitary sensitivity to this hormone. We are not saying that Clomid causes an increase in testosterone levels when taken in during the same 6 weeks, on the contrary, but we do however see the advantage of Nolvadex.
The above difference is apparently due to the difference in the nature of these two estrogen drugs. The researchers clearly support this theory in the comments to their work: “The difference in results can be attributed to weak domestic effect of Clomid, which research has proved an increase in levels transcortin and testosterone / estradiol-binding globulin [SHBG]; this increase was found after tamoxifen. ” In reviewing other theories later in the article, such as the effect of increased levels of androgen or estrogen, they continued to notice that the increase of these hormones was similar when using both drugs and concluded that “… the role of internal estrogenic activity of Clomid which is practically absent in Tamoxifen It seems the most likely explanation. ”
Although both are similar priparaty antiestrogens, they act very differently in different places.Apparently Nolvadex antiestrogen is strong in the hypothalamus and the pituitary gland, unlike Clomid, which although is a potent antiestrogen in the hypothalamus, apparently exhibits a weak estrogenic effect in the pituitary. To find a confirmation of this, we can look at the laboratory animal studies, published by the American Journal of Physiology in February 1981 (2). This work considers the action of Clomid and Nolvadex on the GnRH due to the production of luteinizing hormone by cultured rat pituitary cells. In this paper it was shown that growing cells called Clomid direct estrogenic effect on the sensitivity of the cultured cells, causing a weaker, but still significant effect compared to estradiol.On the other hand Nolvadex has not any appreciable effect on the production of luteinizing hormone.Furthermore, it blocked the effects of estrogen gently when both were cultivated in the same culture.
Briefly summarizing the above studies, Nolvadex is a pure antiestrogen of these two drugs, at least if we consider the axis hypothalamus-pituitary-testes. This fact enables Nolvadex Clomid advantage in male bodybuilders. This is especially true when we consider the rebalancing in the hypothalamic-pituitary-testes, and do not want to reduce the sensitivity of the pituitary to GnRH. The presence of Clomid to raise LH to the same level as is possible in some way slow down the recovery, as the pituitary gland will need large amounts of GnRH from the hypothalamus.
Nolvadex is also preferable for long-term use, for those who find anti-estrogens effective enough at raising testosterone levels to use as anabolic steroids. In this case, Nolvadex would provide a better and more stable increase in testosterone levels and presumably would give similar or stronger effeks than Clomid for considerably less money. The potential increase in testosterone / estradiol-binding globulin Clomid confirmed by another study (3) is also a matter of concern, as it may lead to a relatively lower level of active free testosterone compared to Nolvadex. Of course, both drugs are effective anti-estrogen to prevent gynecomastia and raising the level of endogenous testosterone, however the above research result for me is enough evidence to choose Nolvadex for all occasions.
The following month, in the continuation of this article, I will discuss the role of anti-estrogens in post-cycle testosterone recovery. More precisely, in detail and show you how to look the right post-cycle therapy and explain why some anti-estrogens are not effective in this period of time.